4-Bromo-2-chloro-pyridine is a useful synthetic intermediate. It is used to synthesize 3-[[4-(2-Methoxyphenyl)-2-pyridinyl]amino]-benzenemethanesulfonamide which is a potent CDK9 inhibitor in midline carcinoma therapy. It can also be used to prepare (pyrimidinylamino)benzamide derivatives that have anticancer activity as hedgehog signaling pathway inhibitor.
精確質量:190.91400
PSA:12.89000
LogP:2.49750
2-溴-4-氯吡啶(CAS:22918-01-0)物化性質
外觀與性狀:灰白色結晶
密度:1.7336 g/mL at 25 °C(lit.)
熔點:27ºC
沸點:70 °C / 3mmHg
閃點:225 °F
折射率:n20/D 1.5900(lit.)
2-溴-4-氯吡啶(CAS:22918-01-0)安全信息
危害聲明:H302; H315; H318; H335
警示性聲明:P261; P280; P305 + P351 + P338
海關編碼:2933399090
WGK Germany:3
危險類別碼:R22; R37/38; R41
安全說明:S26-S36
危險品標志:Xn
2-溴-4-氯吡啶(CAS:22918-01-0)用途
可用于有機合成。